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KMID : 0914820150150040290
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Journal of the Korean Gastric Cancer Association
2015 Volume.15 No. 4 p.290 ~ p.294
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C-Kit-Negative Gastrointestinal Stromal Tumor in the Stomach
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Seo Ho-Seok
Hyeon Ji-Yeon
Shin Ok-Ran
Lee Han-Hong
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Abstract
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C-kit-negative gastrointestinal stromal tumors (GISTs) are uncommon, and there have been few reports about the diagnosis and treatment of c-kit-negative GISTs in the stomach. We report the case of a patient who was diagnosed with a huge and atypical GIST in the stomach. The GIST was completely resected and finally diagnosed as c-kit-negative GIST based on immunohistochemical staining of tumor cells, which were negative for CD117 and CD34 and positive for Discovered on GIST-1 (DOG1). C-kit-negative GISTs could be treated by complete resection and/or imatinib, which is the same treatment for c-kit-positive GISTs.
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KEYWORD
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C-kit protein, DOG1 protein, Gastrointestinal stromal tumors
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